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GLP-1 activation has several effects on your digestive system that directly cause GI symptoms: Delayed gastric emptying: Food stays in your stomach longer, causing fullness and sometimes nausea Altered intestinal motility: Changes in how quickly food moves through your intestines can cause either diarrhea or constipation Reduced appetite signals: Your brain receives signals to eat less, which changes your entire digestive rhythm Changes in bile acid secretion: This affects fat digestion and can contribute to loose stools Gut hormone changes: Multiple digestive hormones are affected, altering the normal digestive process Mounjaro Diarrhea: Causes, Duration, and Treatment Why Does Mounjaro Cause Diarrhea
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(3) False-negative analysis was conducted by artificially augmenting the reported incidence of GLP-1RA-associated SSIBs by 100%, aiming to ascertain whether the absence of positive findings could be attributed to our exclusion of some cases involving the concurrent use of multiple GLP-1RAs
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However, they also have some side effects, with many patients experiencing nausea, vomiting and diarrhea
Then his doctor started him on Mounjaro (tirzepatide)
